Which pair correctly matches a disease with its status (Philippines vs world)?

Which pair correctly matches a disease with its status (Philippines vs world)?

• A. Maple Syrup Urine Disease — Most common in the Philippines
• B. G6PD Deficiency — Most common in the Philippines
• C. Maple Syrup Urine Disease — Most common worldwide
• D. G6PD Deficiency — Most common worldwide

Answer: (D)

The key idea is how these conditions distribute across populations. G6PD deficiency is the most common human enzyme deficiency worldwide, found in many populations and carried through generations with relatively high prevalence in diverse ethnic groups. It’s well known for causing hemolysis under oxidative stress (such as certain drugs, infections, or fava beans) and is a classic example of a widely distributed metabolic trait. Maple syrup urine disease, on the other hand, is a very rare metabolic disorder caused by a deficiency in branched-chain amino acid metabolism; it is not common anywhere on a global scale, including the Philippines. So the pair that correctly matches a disease with its status is G6PD deficiency as the most common worldwide.

The key idea is how these conditions distribute across populations. G6PD deficiency is the most common human enzyme deficiency worldwide, found in many populations and carried through generations with relatively high prevalence in diverse ethnic groups. It’s well known for causing hemolysis under oxidative stress (such as certain drugs, infections, or fava beans) and is a classic example of a widely distributed metabolic trait. Maple syrup urine disease, on the other hand, is a very rare metabolic disorder caused by a deficiency in branched-chain amino acid metabolism; it is not common anywhere on a global scale, including the Philippines. So the pair that correctly matches a disease with its status is G6PD deficiency as the most common worldwide.